Apoptotic cell clearance in systemic lupus erythematosus: I. Opsonization by antiphospholipid antibodies
نویسندگان
چکیده
منابع مشابه
Disturbances of apoptotic cell clearance in systemic lupus erythematosus
Systemic lupus erythematosus is a multifactorial autoimmune disease with an as yet unknown etiopathogenesis. It is widely thought that self-immunization in systemic lupus is driven by defective clearance of dead and dying cells. In lupus patients, large numbers of apoptotic cells accumulate in various tissues including germinal centers. In the present review, we discuss the danger signals relea...
متن کاملAntiphospholipid antibodies in systemic lupus erythematosus and the antiphospholipid syndrome.
The family of autoantibodies known as antiphospholipid antibodies (aPL) and the lupus anticoagulant (LA) are associated with a spectrum of clinical manifestations including life-threatening thrombosis. While our current knowledge of thrombosis is imperfect and the mere presence of aPL is imprecisely associated with clinical events, our knowledge in this area has greatly expanded in recent years...
متن کاملAnti-CD40 antibodies in antiphospholipid syndrome and systemic lupus erythematosus.
Anti-beta2glycoprotein I (anti-beta2GPI) antibodies constitute the main autoantibody specificity in the sera of patients with antiphospholipid syndrome (APS). There is evidence that anti-beta2GPI antibodies induce the precoagulant activity of the endothelium by cross-linking the beta2 glycoprotein I (beta2GPI) on the cell surface. Since beta2GPI lacks intracellular domains, homology with other ...
متن کاملThe clinical significance of antiphospholipid antibodies in systemic lupus erythematosus.
Antiphospholipid syndrome (APS) is the association of thrombosis and/or pregnancy morbidity with antiphospholipid antibodies (aPL). Thirty to forty percent of systemic lupus erythematosus (SLE) patients are tested positive for aPL, which may have an impact on the SLE presentation, management, and prognosis. Compared with SLE patients without aPL, those with aPL have a higher prevalence of throm...
متن کاملChorea in systemic lupus erythematosus: association with antiphospholipid antibodies.
Chorea is a rare manifestation of systemic lupus erythematosus (SLE). In this report the clinical features of two cases of chorea associated with SLE are presented. Of special interest were the raised titres of antiphospholipid antibodies in both cases. The possible pathogenic role of these antibodies is briefly discussed.
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1998
ISSN: 0004-3591,1529-0131
DOI: 10.1002/1529-0131(199802)41:2<205::aid-art4>3.0.co;2-0